Publikationen

Winkler, R. Mägdefrau, A., Piskor, E.-M., Kleemann, M., Beyer, M., Linke, K., Hansen, L., Schaffer, A.-M., Hoffmann, M.E., Poepsel, S., Heyd, F., Beli, P., Möröy, T., Mahboobi, S., Krämer, O.H., Kosan, C. Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition. (Pre-print 2021). bioRxiv 2021.06.01.445760; doi: https://doi.org/10.1101/2021.06.01.445760

Joshi, G.; Eberhardt, A.O.; Lange, L.; Winkler, R.; Hoffmann, S.; Kosan, C.; Bierhoff, H. Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell Lymphomagenesis. Cancers (Basel) 2020, 12, doi:10.3390/cancers12103009.

Ross J., Rashkovan M., ..., Winkler R., Arnaud Droit, Kosan C. and Möröy T. (2019). Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models. Cancer Research July 4, 2019; doi: 10.1158/0008-5472.CAN-18-3038

Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, ..., Hübner CA (2019). A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Neurobiology of Desease (19)30079-8, doi: 10.1016/j.nbd.2019.03.026.

Kosan, C., Heidel, F. H., Godmann, M., & Bierhoff, H. (2018). Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging. Cells, 7(12). doi:10.3390/cells7120237

Hartleben, G., Muller, C., Kramer, A., Schimmel, H., Zidek, L. M., Dornblut, C., Winkler R.,. . ., Kosan C.,... Calkhoven, C. F. (2018). Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma. EMBO J, 37(21). doi:10.15252/embj.201798589

Kosan, C., & Godmann, M. (2017). Bringing light into gene regulation in hematopoietic stem cells by the Mediator complex. Stem Cell Investig, 4, 10. doi:10.21037/sci.2017.01.04

Winkler, R., & Kosan, C. (2017). Effects of HDACi on Immunological Functions. Methods Mol Biol, 1510, 93-101. doi:10.1007/978-1-4939-6527-4_7

Buttner, R., Berndt, A., Valkova, C., Richter, P., Korn, A., Kosan, C., & Liebmann, C. (2017). Myofibroblasts have an impact on expression, dimerization and signaling of different ErbB receptors in OSCC cells. J Recept Signal Transduct Res, 37(1), 25-37. doi:10.3109/10799893.2016.1155066

Kosan, C., & Godmann, M. (2016). Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells Int, 2016, 5178965. doi:10.1155/2016/5178965

Kong, Y., Li, Y., Zhang, W., Yuan, S., Winkler, R., Krohnert, U., . . . , Kosan C., Zeng, H. (2016). Sepsis-Induced Thymic Atrophy Is Associated with Defects in Early Lymphopoiesis. Stem Cells, 34(12), 2902-2915. doi:10.1002/stem.2464

Inhalt

Rashkovan, M., Vadnais, C., Ross, J., Gigoux, M., Suh, W. K., Gu, W., . . . , Kosan C., Moroy, T. (2014). Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc Natl Acad Sci U S A, 111(50), E5411-5419. doi:10.1073/pnas.1412107111

Kosan, C., Rashkovan, M., Ross, J., Schaffer, A. M., Saba, I., Lemsaddek, W., . . . Moroy, T. (2014). The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis. Am J Blood Res, 4(1), 7-19.

Ginter, T., Fahrer, J., Krohnert, U., Fetz, V., Garrone, A., Stauber, R. H., . . . , Kosan C., Heinzel T., Kramer, O. H. (2014). Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3. Cell Signal, 26(8), 1698-1706. doi:10.1016/j.cellsig.2014.03.033

Phelan, J. D., Saba, I., Zeng, H., Kosan, C., Messer, M. S., Olsson, H. A., . . . Grimes, H. L. (2013). Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLoS Genet, 9(9), e1003713. doi:10.1371/journal.pgen.1003713

Kosan, C., Ginter, T., Heinzel, T., & Kramer, O. H. (2013). STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis. JAKSTAT, 2(4), e26102. doi:10.4161/jkst.26102

Vassen, L., Duhrsen, U., Kosan, C., Zeng, H., & Moroy, T. (2012). Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48. Am J Blood Res, 2(4), 228-242.

Saba, I., Kosan, C., Vassen, L., & Moroy, T. (2011). IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood, 117(12), 3370-3381. doi:10.1182/blood-2010-09-310680

Saba, I., Kosan, C., Vassen, L., Klein-Hitpass, L., & Moroy, T. (2011). Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint. J Immunol, 187(6), 2982-2992. doi:10.4049/jimmunol.1101451

Moroy, T., Saba, I., & Kosan, C. (2011). The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference. Semin Immunol, 23(5), 379-387. doi:10.1016/j.smim.2011.09.001

Khandanpour, C., Kosan, C., Gaudreau, M. C., Duhrsen, U., Hebert, J., Zeng, H., & Moroy, T. (2011). Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells, 29(2), 376-385. doi:10.1002/stem.575

van Riggelen, J., Muller, J., Otto, T., Beuger, V., Yetil, A., Choi, P. S., . . . , Kosan C., . . ., Eilers, M. (2010). The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev, 24(12), 1281-1294. doi:10.1101/gad.585710

Sharif-Askari, E., Vassen, L., Kosan, C., Khandanpour, C., Gaudreau, M. C., Heyd, F., . . . Moroy, T. (2010). Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol, 30(16), 3929-3942. doi:10.1128/MCB.00087-10

Kosan, C., Saba, I., Godmann, M., Herold, S., Herkert, B., Eilers, M., & Moroy, T. (2010). Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity, 33(6), 917-928. doi:10.1016/j.immuni.2010.11.028

Khandanpour, C., Sharif-Askari, E., Vassen, L., Gaudreau, M. C., Zhu, J., Paul, W. E., . . ., Kosan C., Moroy, T. (2010). Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood, 116(24), 5149-5161. doi:10.1182/blood-2010-04-280305

Igwe, E., Kosan, C., Khandanpour, C., Sharif-Askari, E., Brune, B., & Moroy, T. (2008). The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts. Eur J Immunol, 38(11), 3004-3014. doi:10.1002/eji.200838251

Pargmann, D., Yucel, R., Kosan, C., Saba, I., Klein-Hitpass, L., Schimmer, S., . . . Moroy, T. (2007). Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol, 37(12), 3551-3563. doi:10.1002/eji.200737130

Gebhardt, A., Kosan, C., Herkert, B., Moroy, T., Lutz, W., Eilers, M., & Elsasser, H. P. (2007). Miz1 is required for hair follicle structure and hair morphogenesis. J Cell Sci, 120(Pt 15), 2586-2593. doi:10.1242/jcs.007104

Bachmann, M., Kosan, C., Xing, P. X., Montenarh, M., Hoffmann, I., & Moroy, T. (2006). The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol, 38(3), 430-443. doi:10.1016/j.biocel.2005.10.010

Zeng, H., Yucel, R., Kosan, C., Klein-Hitpass, L., & Moroy, T. (2004). Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J, 23(20), 4116-4125. doi:10.1038/sj.emboj.7600419

Yucel, R., Kosan, C., Heyd, F., & Moroy, T. (2004). Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J Biol Chem, 279(39), 40906-40917. doi:10.1074/jbc.M400808200

Kosan, C., Heidel, F. H., Godmann, M., & Bierhoff, H. (2018). Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging. Cells, 7(12). doi:10.3390/cells7120237

Hartleben, G., Muller, C., Kramer, A., Schimmel, H., Zidek, L. M., Dornblut, C., Winkler R.,. . ., Kosan C.,... Calkhoven, C. F. (2018). Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma. EMBO J, 37(21). doi:10.15252/embj.201798589

Kosan, C., & Godmann, M. (2017). Bringing light into gene regulation in hematopoietic stem cells by the Mediator complex. Stem Cell Investig, 4, 10. doi:10.21037/sci.2017.01.04

Winkler, R., & Kosan, C. (2017). Effects of HDACi on Immunological Functions. Methods Mol Biol, 1510, 93-101. doi:10.1007/978-1-4939-6527-4_7

Buttner, R., Berndt, A., Valkova, C., Richter, P., Korn, A., Kosan, C., & Liebmann, C. (2017). Myofibroblasts have an impact on expression, dimerization and signaling of different ErbB receptors in OSCC cells. J Recept Signal Transduct Res, 37(1), 25-37. doi:10.3109/10799893.2016.1155066

Kosan, C., & Godmann, M. (2016). Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells Int, 2016, 5178965. doi:10.1155/2016/5178965

Kong, Y., Li, Y., Zhang, W., Yuan, S., Winkler, R., Krohnert, U., . . . , Kosan C., Zeng, H. (2016). Sepsis-Induced Thymic Atrophy Is Associated with Defects in Early Lymphopoiesis. Stem Cells, 34(12), 2902-2915. doi:10.1002/stem.2464

Inhalt

Rashkovan, M., Vadnais, C., Ross, J., Gigoux, M., Suh, W. K., Gu, W., . . . , Kosan C., Moroy, T. (2014). Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc Natl Acad Sci U S A, 111(50), E5411-5419. doi:10.1073/pnas.1412107111

Kosan, C., Rashkovan, M., Ross, J., Schaffer, A. M., Saba, I., Lemsaddek, W., . . . Moroy, T. (2014). The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis. Am J Blood Res, 4(1), 7-19.

Ginter, T., Fahrer, J., Krohnert, U., Fetz, V., Garrone, A., Stauber, R. H., . . . , Kosan C., Heinzel T., Kramer, O. H. (2014). Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3. Cell Signal, 26(8), 1698-1706. doi:10.1016/j.cellsig.2014.03.033

Phelan, J. D., Saba, I., Zeng, H., Kosan, C., Messer, M. S., Olsson, H. A., . . . Grimes, H. L. (2013). Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLoS Genet, 9(9), e1003713. doi:10.1371/journal.pgen.1003713

Kosan, C., Ginter, T., Heinzel, T., & Kramer, O. H. (2013). STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis. JAKSTAT, 2(4), e26102. doi:10.4161/jkst.26102

Vassen, L., Duhrsen, U., Kosan, C., Zeng, H., & Moroy, T. (2012). Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48. Am J Blood Res, 2(4), 228-242.

Saba, I., Kosan, C., Vassen, L., & Moroy, T. (2011). IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood, 117(12), 3370-3381. doi:10.1182/blood-2010-09-310680

Saba, I., Kosan, C., Vassen, L., Klein-Hitpass, L., & Moroy, T. (2011). Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint. J Immunol, 187(6), 2982-2992. doi:10.4049/jimmunol.1101451

Moroy, T., Saba, I., & Kosan, C. (2011). The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference. Semin Immunol, 23(5), 379-387. doi:10.1016/j.smim.2011.09.001

Khandanpour, C., Kosan, C., Gaudreau, M. C., Duhrsen, U., Hebert, J., Zeng, H., & Moroy, T. (2011). Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells, 29(2), 376-385. doi:10.1002/stem.575

van Riggelen, J., Muller, J., Otto, T., Beuger, V., Yetil, A., Choi, P. S., . . . , Kosan C., . . ., Eilers, M. (2010). The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev, 24(12), 1281-1294. doi:10.1101/gad.585710

Sharif-Askari, E., Vassen, L., Kosan, C., Khandanpour, C., Gaudreau, M. C., Heyd, F., . . . Moroy, T. (2010). Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol, 30(16), 3929-3942. doi:10.1128/MCB.00087-10

Kosan, C., Saba, I., Godmann, M., Herold, S., Herkert, B., Eilers, M., & Moroy, T. (2010). Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity, 33(6), 917-928. doi:10.1016/j.immuni.2010.11.028

Khandanpour, C., Sharif-Askari, E., Vassen, L., Gaudreau, M. C., Zhu, J., Paul, W. E., . . ., Kosan C., Moroy, T. (2010). Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood, 116(24), 5149-5161. doi:10.1182/blood-2010-04-280305

Igwe, E., Kosan, C., Khandanpour, C., Sharif-Askari, E., Brune, B., & Moroy, T. (2008). The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts. Eur J Immunol, 38(11), 3004-3014. doi:10.1002/eji.200838251

Pargmann, D., Yucel, R., Kosan, C., Saba, I., Klein-Hitpass, L., Schimmer, S., . . . Moroy, T. (2007). Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol, 37(12), 3551-3563. doi:10.1002/eji.200737130

Gebhardt, A., Kosan, C., Herkert, B., Moroy, T., Lutz, W., Eilers, M., & Elsasser, H. P. (2007). Miz1 is required for hair follicle structure and hair morphogenesis. J Cell Sci, 120(Pt 15), 2586-2593. doi:10.1242/jcs.007104

Bachmann, M., Kosan, C., Xing, P. X., Montenarh, M., Hoffmann, I., & Moroy, T. (2006). The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol, 38(3), 430-443. doi:10.1016/j.biocel.2005.10.010

Zeng, H., Yucel, R., Kosan, C., Klein-Hitpass, L., & Moroy, T. (2004). Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J, 23(20), 4116-4125. doi:10.1038/sj.emboj.7600419

Yucel, R., Kosan, C., Heyd, F., & Moroy, T. (2004). Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J Biol Chem, 279(39), 40906-40917. doi:10.1074/jbc.M400808200