Publications

Rühl, P., A.G. Nair, N. Gawande, S.N.C.W. Dehiwalage, L. Münster, R. Schönherr, S.H. Heinemann
An ultrasensitive fluorescent voltage indicator uncovers the electrical activity of non-excitable cells.
Advanced Science 2307930. doi: 10.1002/advs.202307938. PMID: 38526185

Arlt, F.A., R. Miske, M.-L. Machule, P. Broegger Christensen, S. Mindorf, B. Teegen, K. Borowski, M. Buthut, R. Rößling, E. Sanchez-Sendin. S. van Hoof. C. Cordero-Gómez, I. Bünger, H. Radbruch, A. Kraft, I. Ayzenberg. J. Klausewitz, N. Hansen. C. Timäus, P. Körtvelyessy, T. Postert, K. Baur-Seack, C. Rost, R. Brunkhorst, K. Doppler, N. Haigis, G. Hamann, A. Kunze, A. Stützer, M. Maschke, N. Melzer, F. Rosenow, K. Siebenbrodt, C. Stenør, M. Dichgans, M.K. Georgakis, R. Fang, G.C. Petzold, M. Görtler, I. Zerr, S. Wunderlich, I. Mihaljevic, P. Turko, M. Schmidt Ettrup, E. Buchholz, H. Foverskov Rasmussen, M. Nasouti, I. Talucci, H.M. Maric, S.H. Heinemann, M. Endres, DEMAS study group, L. Komorowski, H. Prüss
KCNA2 Ig2 autoimmunity in neuropsychiatric diseases.
Brain, Behavior, and Immunity 117, 399-411. doi: 10.1016/j.bbi/2024.01.220. PMID: 38309639

Zhang, L., V.R. Besaga, P. Rühl, C. Zou, S.H. Heinemann, Y. Wang, F. Setzpfandt
Probing polarization response of monolayer cell cultures with entangled photon pairs.
Journal of Biophotonics e202400018. doi: 10.1002/jbio.202400018

Alves-Simões, M., L. Teege, C. Tomni, M. Lürkens, A. Schmidt, F. Iseppon, Q. Millet, S. Kühs, I. Katona, J. Weis, S.H. Heinemann, C.A. Huebner, J. Wood, E. Leipold, I. Kurth, N. Haag
Na_V1.8/Na_V1.9 double deletion mildly affects acute pain responses in mice. 
Pain (ahead of print). doi: 10.1097/j.pain.0000000000003411. PMID: 39382328

Hussein, R.A., M. Ahmed,  S.H. Heinemann
Selenomethionine mis-incorporation and redox-dependent voltage-gated sodium channel gain of function.
Journal of Neurochemistry 167(2), 262-276. doi: 10.1111/jnc15957.PMID: 37679952.

Loose, S., A. Lischka, S. Kuehs, C. Nau, S.H. Heinemann, I. Kurth, E. Leipold
Peripheral temperature dysregulation associated with functionally altered Na_V1.8 channels.
Pflügers Archiv 175(11), 1343-1355. doi: 10.1007/s00424-023-02856-2. PMID: 37695396

Hussein, R.A., M. Ahmed, N. Kuldyushev, R. Schönherr, S.H. Heinemann
Selenomethionine incorporation in proteins of individual mammalian cells determined with a genetically encoded fluorescent sensor.
Free Radical Biology and Medicine 192, 191-199. doi: 10.1016/j.freeradbiomed.2022.09.019. PMID: 36152916

Gessner, G., M. Jamili, P. Tomcyzk, D. Menche, R. Schönherr, T. Hoshi, S.H. Heinemann
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na⁺ channels.
Biological Chemistry 403(11-12), 1067-1081. doi: 10.1515/hsz-2022-0194. PMID: 36038266

Sahoo, N., I. Coburger, K. Yang, A. Bernert, S.M. Swain, G. Gessner, R. Kappl, T. Kühl, D. Imhof, T. Hoshi, R. Schönherr, S.H. Heinemann
Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.
Scientific Reports 12, 14645. doi: 10.1038/s41598-022-18975-2. PMID: 36030326

Kuldyushev, N., R. Schönherr, I. Coburger, M. Ahmed, R.A. Hussein, E. Wiesel, A. Godbole, T. Pfirrmann, T. Hoshi, S.H. Heinemann
A GFP-based fluorescent sensor for methionine oxidation.
Talanta 243, 123332. https://doi.org/10.1016/j.talanta.2022.123332External link. PMID: 35276500

Pirschel, W., A.N. Mestekemper, B. Wissuwa, N. Krieg, S. Kröller, C. Daniel, F. Gunzer, E. Tolosano, M. Bauer, K. Amann, S.H. Heinemann, S.M. Coldewey
Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice.
Kidney Int S0085-2538(22)00016-3. doi: 10.1016/j.kint.2021.12.024. PMID: 35031328

Rühl, P., J.M. Langner, J. Reidel, R. Schönherr, T. Hoshi, S.H. Heinemann
Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators.
Communications Biology 4(1), 1164. PMID: 34620975

Drees, C., P. Rühl, J. Czerny, G. Chandra, J. Bajorath, M. Haase, S.H. Heinemann, J. Piehler
Diffraction-unlimited photomanipulation at the plasma membrane via specifically targeted upconversion nanoparticles.
Nano Letters 21, 8025-8034 https://doi.org/10.1021/acs.nanolett.1c02267External link. PMID: 34519216

Lu, Y., W. Zhang, B. Zhang, S.H. Heinemann, T. Hoshi, S. Hou, G. Zhang
Bilirubin oxidation end products (BOXes) induce neuronal oxidative stress involving the Nrf2 pathway.
Oxidative Medicine and Cellular Longevity Article ID 8869908. DOI: 10.1155/2021/8869908. PMID: 34373769

Rühl, P., D. Wang., F. Garwe, R. Müller, M. Haase, R. Heintzmann, K.W. Krämer, W. Paa, S.H. Heinemann, H. Stafast
Notes on thermometric artefacts by Er³⁺ luminescence band interference.
Journal of Luminescence 232, 117860

Tian, Y., S.H. Heinemann, T. Hoshi
Regulation of large-conductance Ca²⁺- and voltage-gated Slo1 K⁺ channels by electrostatic interactions with auxiliary β subunits.
BioRxiv 2021.02.22.432338. DOI: 10.1101/2021.02.22.432338.

Sussmilch, F.C., J. Böhm, G. Gessner, T. Maierhofer, T.D. Müller, S.H. Heinemann, D. Becker, R. Hedrich
The liverwort Marchantia polymorpha operates a depolarization-activated Slowpoke (SLO) potassium channel that recognizes pH changes in the environment.
BioRxiv 2021.06.01.446568. DOI: 10.1101/2021.06.01.446568

Gessner G., P. Rühl, M. Westerhausen, T. Hoshi, S.H. Heinemann
Fe²⁺-mediated activation of BK_Ca channels by rapid photolysis of CORM-S1 releasing CO and Fe²⁺.
ACS Chemical Biology 15(8) 2098-2106. PMID: 32667185

Böhme, I., R. Schönherr, R. Eberle, A.K. Bosserhoff 
Membrane transporters and channels in melanoma.
Reviews of Physiology, Biochemistry and Pharmacology, Springer, Berlin, Heidelberg,
DOI: 10.1007/112_2020_17. PMID: 32737752

Coburger, I., K. Yang, A. Bernert, E. Wiesel, S.M. Swain, N. Sahoo, R. Schönherr, T. Hoshi, S.H. Heinemann
Impact of intracellular hemin on N-type inactivation of voltage-gated K⁺ channels.
Pflügers Archiv 472 551-560. PMID: 32388729

Wissbrock, A., N.B. Goradia, A. Kumar, A.A. Paul George, T. Kühl, P. Bellstedt, R. Ramachandran, P. Hoffmann, K. Galler, J. Popp, U. Neugebauer, K. Hampel, B. Zimmermann, S. Adam, M. Wiendl, G. Kronke, I. Hamza, S.H. Heinemann, S. Frey, A. Hueber, O. Ohlenschläger, D. Imhof
Structural insights into heme binding to IL-36α proinflammatory cytokine.
Scientific Reports 9 16893. PMID: 31729440

Englert, F.A., R.A. Seidel, K. Galler, Z. Gouveia, M.P. Soares, U. Neugebauer, M.G. Clemens, C. Sponholz, S.H. Heinemann, G. Pohnert, M. Bauer, S. Weis
Labile heme impairs hepatic microcirculation and promotes hepatic injury.
Archives of Biochemistry and Biophysics 672 108075. PMID: 31412260

Ojha, N.K., J. Jin, J.C. Arifin, P. Rühl, S.H. Heinemann
Membrane potential manipulation with visible flash lamp illumination of targeted microbeads.
Biochemical and Biophysical Research Communications 517(2) 297-302. PMID: 31353087

Paul George, A.A., P. Heimer, E. Leipold, T. Schmitz, D. Kaufmann, D. Tietze, S.H. Heinemann, D. Imhof
Effect of conformational diversity on the bioactivity of µ-conotoxin PIIIA disulfide isomers.
Marine Drugs 17 390. PMID: 31269696

Fischer, D., G. Gessner, T.P. Fill, R. Barnett, K. Tron, K. Dornblut, F. Kloss, P. Stallforth, B. Hube, S.H. Heinemann, C. Hertweck, K. Scherlach, S. Brunke
Disruption of membrane integrity by the bacteria-derived antifungal jagaricin.
Antimicrobial Agents and Chemotherapy 63(9). PMID: 31235622

Prüß, H., G. Gessner, S.H. Heinemann, F. Rüschendorf, A.-K. Ruppert, H. Schulz, T. Sander, W. Rimpau
Linkage evidence for a two-locus inheritance of LQT-associated seizures in a multigenerational LQT family with a novel KCNQ1 loss-of-function mutation.
Frontiers in Neurology 10 648. PMID: 31293497

Andrushchenko, V., W. Pohle
Influence of the hydrophobic domain on the self-assembly and hydrogen bonding of hydroxy-amphiphiles.
Physical Chemistry Chemical Physics 21 11242-11258. PMID: 31099371

Tian, Y., S.H. Heinemann, T. Hoshi
Large-conductance Ca²⁺- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle.
Proceedings of the National Academy of Sciences USA 116(17) 8591-8596. PMID: 30967508

Gessner, G., Runge, S., M. Koenen, S.H. Heinemann, M. Koenen, J. Haas, B. Meder, D. Thomas, H.A. Katurs, P.A. Schweizer
ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.
Biochemical and Biophysical Research Communications 512(4) 845-851. PMID: 30929919

Peigneur, S., O. Cheneval, M. Maiti, E. Leipold, S.H. Heinemann, E. Lescrinier, P. Herdewijn, M.E. DeLima, D.J. Craik, C.I. Schroeder, J. Tytgat
Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.
The FASEB Journal 33(3) 3693-3703. PMID: 30509130

Yang, K., I. Coburger, J. Langner, N. Peter, T. Hoshi, R. Schönherr, S.H. Heinemann
Modulation of K⁺ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.
Pflügers Archiv – European Journal of Physiology 471 557-571. PMID: 30415410

Jentho, E., T. Lajqi, K. Yang, R. Winkler, M. Stojiljkovic, R. Wetzker, M. Bauer
Pathogen-induced hormetic responses
in: "The Science of Hormesis in Health and Longevity" (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press p. 326

Wissuwa, B., S.H. Heinemann, M. Bauer, S.M. Coldewey
Studies into Slo1 K⁺ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition.
Life Sciences 203 112-120. PMID: 29684444

Martin, C., C. Stoffer, M. Mohammadi, J. Hugo, E. Leipold, B. Oehler, H.L. Rittner, R. Blum
Na_V1.9 potentiates oxidized phospholipid-induced TRP responses only under inflammatory conditions.
Frontiers in Molecular Neuroscience 11 7. PMID: 29410612

Mede, R., P. Hoffmann, M. Klein, H. Görls, M. Schmitt, U. Neugebauer, G. Gessner, S.H. Heinemann, J. Popp, M. Westerhausen
A water-soluble Mn(CO)₃-based and non-toxic photoCORM for administration of carbon monoxide inside of cells.
ZAAC - Journal of Inorganic and General Chemistry 643 2057-2062

Gessner, G., N. Sahoo, S.M. Swain, G. Hirth, R. Schönherr, R. Mede, M. Westerhausen, H.H. Brewitz, P. Heimer, D. Imhof, T. Hoshi, S.H.Heinemann
CO-independent modification of K⁺ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).
European Journal of Pharmacology 815 33-41. PMID: 28987271

King, M.K., E. Leipold, J.M. Goehringer, I. Kurth, T.D. Challman
Pain insensitivity: distal S6-segment mutations in Na_V1.9 emerge as critical hotspot.
Neurogenetics 18 179-181. PMID: 28289907

Lolignier, S., D. Gkika, D. Andersson, E. Leipold, I. Vetter, F. Viana, J. Noël, J. Busserolles
New insight in cold pain: role of ion channels, modulation, and clinical perspectives.
Journal of Neuroscience 36 11435-11439. PMID: 27911746

Seidel, R.A., T. Claudel, F.A. Schleser, N.K. Ojha, M. Westerhausen, S. Nietzsche, C. Sponholz, F. Cuperus, S.M. Coldewey, S.H. Heinemann, G. Pohnert, M. Trauner, M. Bauer
Impact of higher-order heme degradation products on hepatic function and hemodynamics.
Journal of Hepatology 67 272-281. PMID: 28412296

Ojha, N.K., E. Leipold, R. Schönherr, T. Hoshi, S.H. Heinemann
Non-photonic sensing of membrane-delimited reactive species with a Na⁺ channel protein containing selenocysteine.
Scientific Reports 7 46003. PMID: 28378799

Mede, R., J. Traber, M. Klein, H. Görls, G. Gessner, P. Hoffmann, M. Schmitt, J. Popp, S.H. Heinemann, U. Neugebauer, M. Westerhausen
Synthesis and solution stability of water-soluble κ²N,κO-bis(3,4-dimethylpyrazolyl)ethanol manganese(I) tricabonyl bromide (CORM-ONN1).
Dalton Transactions 46 1684-1693. PMID: 28102423

Leipold, E., F. Ullrich, M. Thiele, A.A. Tietze, H. Terlau, D. Imhof, S.H. HeinemannSubtype-specific block of voltage-gated K⁺ channels by µ-conopeptides.
Biochemical and Biophysical Research Communications 482 1135-1140. PMID: 27916464

Jadhav, K.B., C. Stein, O. Makarewicz, R.J. Lichtenecker, G. Pradel, H. Sack, S.H. Heinemann, H.-D. Arndt
Bioactivity of topologically confined gramicidin A dimers.
Bioorganic & Medicinal Chemistry 25 261-268. PMID: 27865644

Tian, Y., M. Aursnes, T.V. Hansen, J. Galpin, L. Leisle, C. Ahern, R. Xu, S.H. Heinemann, T. Hoshi
Atomic determinants of BK channel activation by polyunsaturated fatty acids.
Proceedings of the National Academy of Sciences USA 113(48) 13905-13910  PMID: 27849612

Marques-Carvalho, M.J., J. Oppermann, E. Munoz, A.S. Fernandes, G. Gabant, M. Cadene, S.H. Heinemann, R. Schönherr, J.H. Morais-Cabral
Molecular insights into the mechanism of calmodulin inhibition of the EAG1 potassium channel.
Structure 24 1-13 PMID: 27618660

Tietze, D., E. Leipold, P. Heimer, M. Böhm, W. Winschel, D. Imhof, S.H. Heinemann, A.A. Tietze
Molecular interaction of δ-conopeptide EVIA with voltage-gated Na⁺ channels.
Biochimica et Biophysica Acta General Subjects 1860 2053-2063 PMID: 27316322

Zhu, Q., R. El-Mergawy, Y. Zhou, C. Chen, S.H. Heinemann, R. Schönherr, D. Robaa, W. Sippl, G.K.E. Scriba
Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.
Electrophoresis 37 2083-2090 PMID: 27145186

Hoshi, T., S.H. HeinemannModulation of BK channels by small endogenous molecules and pharmaceutical channel openers.
International Review of Neurobiology 128 193-237 PMID: 27238265

Han, B., M. Zhang, K. He, C. Cai, Y. Tang, L. Yang, S.H. Heinemann, T. Hoshi, S. Hou
Human EAG channels are directly modulated by PIP₂ as revealed by electrophysiological and optical interference investigations.
Scientific Reports 6 23417 PMID: 27005320

Mede, R., M. Klein, R.A. Claus, S. Krieck, S. Quickert, H. Görls, U. Neugebauer, M. Schmitt, G. Gessner, S.H. Heinemann, J. Popp, M. Bauer, M. Westerhausen
CORM-EDE1 A highly water-soluble and non-toxic manganese-based photoCORM with a biogenic ligand sphere.
Inorganic Chemistry 55 104-113 PMID: 26672620

Schink, M., E. Leipold, J. Schirmeyer, R. Schönherr, T. Hoshi, S.H. Heinemann
Reactive species modify Na_V1.8 channels and affect action potentials in murine dorsal root ganglion neurons.
Pflügers Archiv, European Journal of Physiology 468 99-110 PMID: 26383867

Leipold, E., A. Hanson-Kahn, M. Frick, P. Gong, J.A. Bernstein, M. Voigt, I. Katona, R.O. Goral, J. Altmüller, P. Nürnberg, J. Weiss, C.A. Hübner, S.H. Heinemann, I. Kurth
Cold-aggravated pain in humans caused by a hyperactive Na_V1.9 channel mutant.
Nature Communications 6 10049 PMID: 26645915

Swain, S.M., N. Sahoo, S. Dennhardt, R. Schönherr, S.H. Heinemann
Ca²⁺/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K⁺ channels.
Scientific Reports 5 15509 doi: 10.1038/srep15509 PMID: 26487174

Bode, H.B., A.O. Brachmann, K.B. Jadhav, L. Seyfarth, C. Dauth, S.W. Fuchs, M. Kaiser, N.R. Waterfield, H. Sack, S.H. Heinemann, H.D. Arndt
Structure elucidation and activity of kolossin A, the D-/L-pentadecapeptide product of a giant nonribosomal peptide synthetase.
Angewandte Chemie International Edition 54(35) 10352-10355 PMID: 26118790

Goral, R.O., E. Leipold, E. Nematian-Ardestani, S.H. Heinemann
Heterologous expression of Na_V1.9 chimeras in various cell systems.  
Pflügers Archiv, European Journal of Physiology 467 2423-2435 PMID: 25916202

Tian, Y., F. Ullrich, R. Xu, S.H. Heinemann, S. Hou, T. Hoshi
Two distinct effects of PIP₂ underlie auxiliary subunit-dependent modulation of Slo1 BK channels.
Journal of General Physiology 145 331-343 PMID: 25825171

Friebel, K., R. Schönherr, R.W. Kinne, E. Kunisch
Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients.
Journal of Cellular Physiology 230 1677-1688 PMID: 25545021

Goradia, N., C. Wiedemann, C. Herbst, M. Görlach, S.H. Heinemann, O. Ohlenschläger, R. Ramachandran
An approach to NMR assignment of intrinsically disordered proteins.
ChemPhysChem 16 739-746 PMID: 25639453

Mede, R., V.P. Lorett-Velásquez, M. Klein, H. Görls, M. Schmitt, G. Gessner, S.H. Heinemann, J. Popp, M. Westerhausen
Carbon monoxide release properties and molecular structures of thiophenolatomanganese(I) carbonyl complexes of the type [(OC)₄Mn(µ-S-Aryl)]₂ (Mn-based CORMs).
Dalton Transactions 44 3020-3033 PMID: 25569035

Heimer, P., A.A. Tietze, M. Böhm, R. Giernoth, A. Kuchenbuch, A. Stark, E. Leipold, S.H. Heinemann, C. Kandt, D. Imhof
Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides.
ChemBioChem 15 2754-2765 PMID:25376613

Zhu, Q., S.H. Heinemann, R. Schönherr, G.K.E. Scriba
Capillary electrophoresis separation of peptide diastereomers that contain methionine sulfoxide by dual cyclodextrin-crown ether systems.
Journal of Separation Science 37 3548-3554 PMID:25216019

Zhu, Q., X. Huo, S.H. Heinemann, R. Schönherr, R.G. El-Mergawy, G.K.E. Scriba
Experimental design-guided development of a stereospecific capillary electrophoresis assay for methionine sulfoxide reductase enzymes using a diastereomeric pentapeptide substrate.
Journal of Chromatrography A 1359 224-229 PMID:25064531

Mancini, M., M.V. Soldovieri, G. Gessner, B. Wissuwa, V. Barrese, F. Boscia, A. Secondo, F. Miceli, C. Franco, P. Ambrosino, L.M.T. Canzoniero, M. Bauer, T. Hoshi, S.H. Heinemann, M. Taglialatela
Critical role of large conductance voltage- and calcium-activated potassium channels in leptin-induced neuroprotection of N-methyl-D-aspartate-exposed cortical neurons.
Pharmacological Research 87 80-86 PMID:24973659

Schirmeyer, J., K. Szafranski, E. Leipold, C. Mawrin, M. Platzner, S.H. Heinemann
Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.
Channels 8 210-215 PMID:2463188

Ojha, N.K., E. Nematian-Ardestani, S. Neugebauer, B. Borowski, A. El-Hussein, T. Hoshi, E. Leipold, S.H. Heinemann
Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.
BBA Biomembranes 1838 1412-1419 PMID:24513256

Heinemann, S.H., T. Hoshi, M. Westerhausen, A. Schiller
Carbon monoxide - physiology, detection and controlled release.
Chemical Communications 50 3644-3660 PMID: 24556640

Zhu, Q., R.G. El-Mergawy, S.H. Heinemann, R. Schönherr, P. Jac, G.K.E. Scriba
Stereospecific electrophoretically mediated microanalysis assay for methionine sulfoxide reductase enzymes.
Analytical and Bioanalytical Chemistry 406 1723-1729 PMID:24424966

Ohlenschläger, O., A. Schiller, F. Jahns, S.H. Heinemann
Bunte Aspekte: Häm und seine Abbauprodukte.
Nachrichten aus der Chemie 62 119-124

Glaser, R.W., R. Schönherr, S.H. Heinemann
Fixed charges in the gel matrix of sensor chips and dissociation in diffusion gradients influence the detection of fast protein-protein interactions.
BioSystems 116 27-35 PMID:24342363

Sahoo, N., T. Hoshi, S.H. Heinemann
Oxidative modulation of voltage-gated potassium channels.
Antioxid Redox Signal 21 933-952 PMID:24040918

Hoshi, T., R. Xu, S. Hou, S.H. Heinemann, Y. Tian
A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.
The Journal of General Physiology 142 507-522 PMID: 24127525

Sahoo, N., N. Goradia, O. Ohlenschläger, R. Schönherr, M. Friedrich, W. Plass, R. Kappl, T. Hoshi, S.H. Heinemann
Heme impairs the ball-and-chain inactivation of potassium channels.
Proceedings of the National Academy of Sciences USA Plus 110 E4036-4044 PMID: 24082096

Heinemann, S.H., M. Bauer
Gesundes Fett im Fisch: Blutdrucksenkende Wirkung von Omega-3-Fettsäuren
Labor & more 6.13 44-48

Leipold, E., L. Liebmann, G.C. Korenke, T. Heinrich, S. Gießelmann, J. Baets, M. Ebbinghaus, R.O. Goral, T. Stödberg, J.C. Hennings, M. Bergmann, J. Altmüller, H. Thiele, A. Wetzel, P. Nürnberg, V. Timmerman, P. de Jonghe, R. Blum, H.-G. Schaible, J. Weis, S.H. Heinemann, C.A. Hübner, I. Kurth
A de novo gain-of-function mutation in SCN11A causes loss of pain perception.
Nature Genetics 45 1399-1404 PMID: 24036948

Hoshi, T., B. Wissuwa, T. Tian, N. Tajima, R. Xu, M. Bauer, S.H. Heinemann, S. Hou
Differential impacts of omega-3 fatty acids and their derivatives on blood pressure.
Proceedings of the National Academy of Sciences USA 110 E2260 PMID: 23940844

Zhu, Q., R.G. Abdelaleem, P. Jac, S.H. Heinemann, R. Schönherr, G.K.E. Scriba
Stereospecific micellar electrokinetic chromatography assay of methionine sulfoxide reductase enzymes employing a multiple-layer coated capillary.
Electrophoresis 34 2712-2717 PMID: 23775584

Kühl, T., A. Wißbrock, N. Goradia, N. Sahoo, K. Galler, U. Neugebauer, J. Popp, S.H. Heinemann, O. Ohlenschläger, D. Imhof
Analysis of Fe(III) heme binding to cysteine-containing heme-regulatory motifs in proteins.
ACS Chemical Biology 8 1785-1793 PMID: 23730736

Jazzazi, T.M.A., H. Görls, G. Gessner, S.H. Heinemann, M. Westerhausen
Photosensitive iron(II)-based CO releasing molecules (CORMs) with vicinal amino and diphenylphosphino substituted chelating ligands.
Journal of Organometallic Chemistry 733 63-70

Hoshi, T., B. Wissuwa, Y. Tian, N. Tajima, R. Xu, M. Bauer, S.H. Heinemann, S. Hou
Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.
Proceedings of the National Academy of Sciences USA 110 4816-4821

Hoshi, T., Y. Tian, R. Xu, S.H. Heinemann, S. Hou
Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA.
Proceedings of the National Academy of Sciences USA 110 4822-4827

Pohle, W.
The Potential Binding Potency of Biological Molecules
in:  "Advances in Chemistry Research", Vol. 11 (J. C. Taylor, Ed.) Nova Science Publishers, Hauppauge, New York (2012) pp. 1-74.

Stengel, R., E. Rivera-Milla, N. Sahoo, C. Ebert, F. Bolling, S.H. Heinemann, R. Schönherr, C. Englert
Kcnh1 voltage-gated potassium channels are essential for zebrafish early embryonic development.
Journal of Biological Chemistry 287 35565-35575 PMID: 22927438

Sponholz, C., K. Huse, M. Kramer, E.J. Giamarellos-Bourboulis, R.A. Claus, A. Kern, C. Engel, E. Kuhnt, M. Kiehntopf, C. Routsi, V. Mylona, I. Tsangaris, S.H. Heinemann, K. Reinhart, M. Platzer, M. Bauer
Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.
Shock 38 459-465

Heinemann, S.H.
Visualizing individual sodium channels on the move.
Chemistry and Biology 19 790-791 PMID: 22840766

Quast, S.A., A. Berger, N. Buttstädt, K. Friebel, R. Schönherr, J. Eberle
General sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC.
PLoS One. 2012;7(6):e39290. Epub 2012 Jun 18.

Marques-Carvalho, M.J., N. Sahoo, F.W. Muskett, R.S. Vieira-Pires, G. Gabant, M. Cadene, R. Schönherr, J.H. Morais-Cabral
Structural, biochemical and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel.
Journal of Molecular Biology 423 34-46

Markgraf, R., E. Leipold, J. Schirmeyer, M. Paolini-Bertrand, O. Hartley, S.H. Heinemann
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC.
British Journal of Pharmacology 167 576-586 PMID: 22537004

Leipold, E., A. Borges, S.H. Heinemann
Scorpion β-toxin interference with Na_V channel voltage sensor gives rise to excitatory and depressant modes.
Journal of General Physiology 139 305-319 PMID: 22331907

Tietze, A.A., D. Tietze, O. Ohlenschläger, E. Leipold, F. Ullrich, A. Mischo, M. Görlach, S.H. Heinemann, D. Imhof
Structurally diverse µ-conotoxin PIIIA isomers block sodium channel Na_V1.4.
Angewandte Chemie International Edition 51 4058-4061 PMID: 22407516

Sahoo, N., R. Schönherr, T. Hoshi, S.H. Heinemann
Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels.
Biochimica et Biophysica Acta - Biomembranes 1818 1187-1195 PMID: 22310694

Gessner, G., Y.-M. Cui, Y. Otani, T. Ohwada, M. Soom, T. Hoshi, S.H. Heinemann
Molecular mechanism of pharmacological activation of BK channels.
Proceedings of the National Academy of Sciences, USA 109 3552-3557 PMID: 22331907

Bauer, M., O.W. Witte , S.H. Heinemann
Carbon monoxide and outcome of stroke-A dream CORM true?
Critical Care Medicine 40 687-688 PMID: 22249054

Velasquez, V.P.L., T.M.A. Jazzazi, A. Malassa, H. Görls, G. Gessner, S.H. Heinemann, M. Westerhausen
Derivatives of photosensitive CORM-S1: CO complexes of iron and ruthenium with the (OC)₂M(S-C-C-NH₂)₂ fragment.
European Journal of Inorganic Chemistry 2012 1072-1078

Favreau, Ph., E. Benoit, H.G. Hocking, L. Carlier, D. D'hoedt, E. Leipold, R. Markgraf, S. Schlumberger, M.A. Córdova, H. Gaertner, M. Paolini-Bertrand, O. Hartley, J. Tytgat, S.H. Heinemann, D. Bertrand, R. Boelens, R. Stöcklin, J. Morgó
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of Na_V 1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.
British Journal of Pharmacology 166 1654-1668 PMID: 22229737

Kühl, T., N. Sahoo, M. Nikolajski, B. Schlott, S.H. Heinemann, D. Imhof
Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach.
ChemBioChem 12 2846-2855

Handbook of Biophotonics, Vol. 2: Photonics for Health Care. Edts: J. Popp, V.V. Tuchin, A. Chiou, S.H. Heinemann, WILEY-VCH Verlag & Co. KGaA, Weinheim

Handbook of Biophotonics, Vol. 1: Basics and Techniques. Edts: J. Popp, V.V. Tuchin, A. Chiou, S.H. Heinemann, WILEY-VCH Verlag & Co. KGaA, Weinheim

Leipold, E., R. Markgraf, A. Miloslavina, M. Kijas, J. Schirmeyer, D. Imhof, S.H. Heinemann
Molecular determinants of the subtype specificity of µ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.
Neuropharmacology 61 105-111

Seidel, K.N., C. Derst, M. Salzmann, M. Höltje, J. Priller, R. Markgraf, S.H. Heinemann, H. Heilmann, S.N. Skatchkov, M.J. Eaton, R.W. Veh, H. Prüss
Expression of the voltage- and Ca²⁺-dependent BK potassium channel subunits BKb1 and BKb4 in rodent astrocytes.
Glia 59 893-902

Carella, M., J. Becher, O. Ohlenschläger, R. Ramachandran, K.H. Gührs, G. Wellenreuther, W. Meyer-Klaucke, S.H. Heinemann, M. Görlach
Structure-function relationship in an archaebacterial methionine sulfoxide reductase B.
Molecular Microbiology 79 342-358

Neugebauer, U., S.H. Heinemann, M. Schmitt, J. Popp
Combination of patch clamp and Raman spectroscopy for single-cell analysis.
Analytical Chemistry 83 344-350

Kretschmer, R., G. Gessner, H. Görls, S.H. Heinemann, M. Westerhausen
Dicarbonyl-bis(cysteamine)iron(II): a light induced carbon monoxide releasing molecule based on iron (CORM-S1).
Journal of Inorganic Biochemistry 105 6-9

Hou, S., R. Xu, J.F. Clark, W.L. Wurster, S.H. Heinemann, T. Hoshi
Bilirubin oxidation end products (BOXes) directly alter K⁺ channels important in regulation of vascular tone.
Journal of Cerebral Blood Flow & Metabolism 31 102-112

Baumgart, M., C. Feller, G. Natura, T. Dahse, H.G. Schaible, I. Dahse
Blockade of TTX-resistant and TTX-sensitive Na⁺ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000.
Brain Research 1358 54-63

Sahoo, N., J. Tröger, S.H. Heinemann, R. Schönherr
Current inhibition of human EAG1 potassium channels by the Ca²⁺ binding protein S100B.
FEBS Letters 584 3896-3900

Schmidt, J., K. Friebel, R. Schönherr, M.G. Coppolino, A.K. BosserhoffS
Migration-associated secretion of melanoma inhibitory activity (MIA) at the cell rear is supported by KCa3.1 potassium channels.
Cell Research 20 1224-1238

Gauger, D.R., V.V. Andrushchenko, P. Bour, W. Pohle
A spectroscopic method to estimate the binding potency of amphiphile assemblies.
Analytical and Bioanalytical Chemistry 398 1109-1123

Kolbe, K., R. Schönherr, G. Gessner, N. Sahoo, T. Hoshi, S.H. Heinemann
Cysteine 723 in the C-linker segment confers oxidation inhibition of hERG1 potassium channels.
The Journal of Physiology 588 2999-3009

König, C., O. Gavrilova-Ruch, G. Segond von Bachet, R. Bauer, M. Grün, E. Hirsch, I. Rubio, S. Schulz, S.H. Heinemann, H.G. Schaible, R. Wetzker
Modulation of µ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ.
Neuroscience 169 449-454

Binger, K.J., M.D.W. Griffin, S.H. Heinemann, G.J. Howlett
Methionine oxidized amyloid fibrils are poor substrates for human methionine sulfoxide reductases A & B2.
Biochemistry 49 2981-2983

Eberle, J., B. Spangler, J. Becker, S.H. Heinemann, C.A. Klein, M. Kunz, S. Kuphal, P. Langer, C. Mauch, S. Meierjohann, A. Paschen, D. Schadendorf, M. Schartl, B. Schittek, R. Schönherr, T. Tueting, P. Zigrino, A.K. Bosserhoff
Multicentre study on standardisation of melanoma cell culture - an initiative of the German Melanoma Research Network.
Pigment Cell & Melanoma Research 23 296-298

Gessner, G., R. Macianskiene, J.G. Starkus, R. Schönherr, S.H. Heinemann
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.
European Journal of Pharmacology 632 52-59

Hou, S., L.E. Vigeland, G. Zhang, R. Xu, M. Li, S.H. Heinemann, T. Hoshi
Zn²⁺ activates large-conductane Ca²⁺ -activated K⁺ channel via an intracellular domain.
Journal of Biological Chemistry 285 6434-6442

Zhang, J.T., S. Petersen, M. Thunga, E. Leipold, R. Weidisch, X. Liu, A. Fahr, K.D. Jandt
Micro-structured smart hydrogels with enhanced protein loading and release efficiency
Acta Biomaterialia 6 1297-1306

Schirmeyer, J., K. Szafranski, E. Leipold, C. Mawrin, M. Platzer, S.H. Heinemann
A subtle alternative splicing event of the Na_V1.8 voltage-gated sodium channel is conserved in human, rat, and mouse.
Journal of Molecular Neuroscience 41 310-314

Pohle, W., Gauger, D.R.
Solid-state primary aliphatic amines are actually ammonium amides as revealed by infrared spectroscopy.
Journal of Molecular Structure 924-926 144-147

Wicher, D., R. Schäfer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, B.S. Hansson
dOr83b--receptor or ion channel?
Ann N Y Acad Sci. 1170 164-167

Discher, S., A. Burse, K. Tolzin-Banasch, S.H. Heinemann, J.M. Pasteels, W. Boland
A versatile transport network for sequestering and excreting plant glycosides in leaf beetles provides an evolutionary flexible defense strategy.
Chembiochem 10 2223-2229

Hou, S., F.T. Horrigan, R. Xu, S.H. Heinemann, T. Hoshi
Comparative effects of H⁺ and Ca²⁺ on large-conductance Ca²⁺- and voltage-gated Slo1 K⁺ channels.
Channels 3 249-258

Wassef, R., S.H. Heinemann, T. Hoshi
Treating oxidative neural injury: methionine sulfoxide reductase therapy for Parkinson disease. In S.C. Veasey (ed.) Oxidative Neural Injury.
Humana Press. Contemporary Clinical Neuroscience, 193-206

Hou, S., S.H. Heinemann, T. Hoshi
Modulation of BK_Ca channel gating by endogenous signaling molecules.
Physiology (Bethesda) 24 26-35

Miloslavina, A.A., E. Leipold, M. Kijas, A. Stark, S.H. Heinemann, D. Imhof
A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides.
Journal of Peptide Science 14 72-77

Haenold, R., R. Wassef, N. Brot, S. Neugebauer, E. Leipold, S.H. Heinemann, T. Hoshi
Protection of vascular smooth muscle cells by methionine sulfoxide reductase A Role of intracellular localization and substrate availability.
Free Radical Research 42 978-988

Decher, N., T. Gonzales, A.K. Streit, F.B. Sachse, V. Renigunta, M. Soom, S.H. Heinemann, J. Daut, M.C. Sanguinetti
Structural determinants of Kvβ1.3 induced channel inactivation: a hairpin modulated by PIP₂.
The EMBO Journal 27 3164-3174

Soom M, G. Gessner, H. Heuer, T. Hoshi, S.H. Heinemann
A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function
Channels 2 278-282

Wicher, D., R. Schäfer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, B.S. Hansson
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.
Nature 4521007-1011

Hou, S., R. Xu, S.H. Heinemann, T. Hoshi
Reciprocal regulation of the Ca²⁺ and H⁺ sensitivity in the Slo1 BK channel conferred by the RCK1 domain.
Nature Structural and Molecular Biology  15 403-410

Kassmann, M., A. Hansel, E. Leipold, J. Birkenbeil, S.Q. Lu, T. Hoshi, S.H. Heinemann
Oxidation of multiple methionine residues impairs rapid sodium channel inactivation.
Pflügers Archiv 456 1085-1095

Hou, S., R. Xu, S.H. Heinemann, T. Hoshi
The RCK1 high-affinity Ca²⁺ sensor confers carbon monoxide sensitivity to Slo1 BK channels.
Proceedings of the National Academy of Sciences, USA 105 4039-4043