Publications

Publications from the neuroepigentics team 

Stein, G., Aly, J.S., Lange, L., Manzolillo, A., Riege, K., Brancato, A., Hübner, C.A., Turecki, G., Hoffmann, S., Engmann, O. (2024) Npbwr1 signaling mediates fast antidepressant action. BioRxiv [Link]External link
A PREVIOUSLY UNKNOWN PRODEPRESSIVE PATHWAY IS RESCUED BY A NOVEL FAST-ACTNG COMPOUND

Stein, G. Aly, J.S., Manzolillo, A., Lange, L., Riege, K., Hussain, I., Heller, E.A., Cubillos, S., Ernst, T., Hübner, C.A., Turecki, G., Hoffmann, S., Engmann, O. (2024) Transthyretin orchestrates vitamin B12-induced stress resilience. Biol Psychiatry. 17:S0006-3223(24)01457-4. [Link]External link
IN VIVO EPIGENOME-EDITING OF DNA METHYLATION ON THE TRANSTHYRETIN GENE MIMICS STRESS RESILIENCE BOOSTING EFFECTS OF VITAMIN B12

Cubillos S, Engmann O*, Brancato A. (2022) BDNF as a mediator of antidepressant response: recent advances and lifestyle interactions. Int Journal of Mol Sci. 23, 14445. * corresponding author. [Link]External link
REVIEW ON LIFE STYLE IMPACT ON ANTIDEPRESSANT RESPONSE VIA BDNF (IF = Impact factor, 6.2)

Franzka P, Turecki G, Cubillos S, Kentache T, Steiner J, Walter M, Hübner CA, Engmann O. (2022) Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12. Front Nutrition. 9: 981511 [Link]External link
METABOLIC PATHWAY, WHICH LINKS VITAMIN B12 ANTIDEPRESSANT ACTION TO DEPRESSION RISK

Behrends M, Engmann O. (2021) Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases. Front Genet. 12: 732033. [Link]External link
REVIEW ON CHROMATIN ARCHITECTURE IN MENTAL ILLNESS

Aly J, Engmann O. (2020) The way to a human’s brain goes through their stomach: Dietary factors in major depressive disorder. Frontiers Neuroscience.14: 582853. [Link]External link
REVIEW ON HOW DIETARY FACTORS AFFECT DEPRESSION RISK

Behrends M, Engmann O. (2020) Linker Histone H1.5 is an Underestimated Factor in Differentiation and Carcinogenesis. Environmental Epigenetics. 6: dvaa013. [Link]External link
REVIEW ON CHROMATIN REGULATION BY HISTONE ISOFORMS

Trautmann C, Burek D, Hübner CA, Girault JA, Engmann O. (2020) A regulatory pathway linking caffeine action, mood and the diurnal clock. Neuropharmacology. 172: 108133. [Link]External link
NOVEL PATHWAY LINKING CAFFEINE AND MOOD VIA THE CIRCADIAN CLOCK

Trautmann C, Bock A, Urbach A, Hübner CA, Engmann O. (2020) Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2. Neuropharmacology. 171: 108122. [Link]External link
EVIDENCE THAT VITAMIN B12 HAS FAST-ACTING ANTIDEPRESSANT PROPERTIES IN MICE

Other publications by O. Engmann

Labonté B, Jeong YH, Parise E, Issler O, Fatma M, Engmann O, Cho KA, Neve R, Nestler EJ, Koo JW. (2019) Gadd45b mediates depressive-like role through DNA demethylation. Sci Rep. 9:4615. [Link]External link
NOVEL DEPRESSION-PATHWAY VIA DNA-METHYLATION

Engmann O (2018) Dairy cows – an opportunity in the research field of non-genetic inheritance? Environmental Epigenetics. 4: dvy014. [Link]External link
IMPACT OF MATERNAL SEPARATION ON CALF HEALTH IN DAIRY COWS

Bohacek J, Engmann O, Germain PL, Mansuy IM (2018). Proceedings at the forefront of germline-dependent epigenetic inheritance. Environmental Epigenetics. 4: dvy012. [Link]
EPIGENETIC INHERITANCE: SYMPOSIUM SUMMARY

Kremer EA, Gaur N, Lee MA, Engmann O, Bohacek J, Mansuy IM (2018) Novel interplay between TET proteins and microRNAs in the adult brain for memory formation. Scientific Reports. 8:1678. [Link]External link
NOVEL COGNITIVE PATHWAY VIA DNA-METHYLATION

Marion-Poll L, Besnard A, Longueville S, Valjent E, Engmann O, Hervé D, Girault JA (2018) Cocaine conditioned place preference: unexpected effects of testing combined with strong conditioning conditions. Addiction Biology. 24:364-75. [Link]External link
OPTIMIZATION OF BEHAVIORAL TESTING FOR ADDICTION PARADIGMS

Labonté B, Engmann O, Purushothaman I, Hodes G, Lorsch Z, Hamilton PJ, Calipari E, Scarpa JR, Loh WHE, Issler O, Kronman H, Walker D, Pfau M, Doyle M, Neve R, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ (2017) Sex-Specific Transcriptional Signatures in Human Depression. Nature medicine. 23:1102-1111. [Link]External link
DEPRESSION IS TWO SEX-SPECIFIC DISORDERS AND IS BEST REFLECTED BY THE CVS-MOUSE MODEL

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh EDW, Walker DM, Burek D, Hamilton P, Issler O, Neve R, Turecki G, Hurd Y, Li S, Chess A, Jeltsch A, Akbarian S, Nestler EJ (2017) The largest number of cocaine-induced changes in chromatin modifications are associated with increased expression and 3D looping of Auts2. Biological Psychiatry. 82:794-805. [Link]External link
CHROMATIN LOOPING CONTRIBUTES TO ADDICTION-PHENOTYPES

Feng J, Pena CJ, Purushothaman I, Engmann O, Walker D, Brown AN, Issler O, Doyle M, Harrigan E, Mouzon E, Vialou V, Shen L, Dawlaty MM, Jänisch R, Nestler EJ (2017) Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors. Neuropsychopharmacology. 42:1657-1669. [Link]External link
NOVEL DEPRESSION-PATHWAY VIA DNA-METHYLATION

Engmann O, Giralt A, Girault JA (2016) Acute drug-induced spine changes in the nucleus accumbens are dependent on beta-adducin. Neuropharmacology. 110:333-42. [Link]External link
PSYCHOSTIMULANT AND ANTIPSYCHOTIC DRUGS RAPIDLY AFFECT DENDRITIC SPINES IN THE NUCLEUS ACCUMBENS WITH DRUG-SPECIFIC PROFILES

Koo JW, Labonté B, Engmann O, Calipari E, Juarez B, Lorsch Z, Walsh J, Friedman A, Han MU, Nestler EJ (2015) Essential role of mesolimbic brain-derived neurotrophic factor in chronic social stress-induced depressive behaviors Biol. Psychiatry. S0006-3223:01045-8. [Link]External link
BDNF CONTRIBUTES TO DEPRESSION-PHENOTYPES VIA VTA-TO-NAC BRAIN CIRCUIT

Engmann O, Gervasi N, Giralt A, Marion-Poll A, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault, JA (2015) DARPP-32 interaction with adducin: a possible mediator of rapid environmental effects on striatal neurons. Nature communications. 6:10099. [Link]External link
NEW INTERACTION PARTNER OF DARPP-32 ; RAPID ENVIRONMENTAL ENRICHMENT EFFECTS ON SYNAPSES AND BEHAVIOR

Tiwari SS, d'Orange M, Troakes C, Shurovi BN, Engmann O, Noble W, Hortobágyi T, Giese KP (2015) Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease. Mol Brain. 8:6. [Link]External link
IDENTIFICATION OF A NEUROPROTECTIVE MOLECULE

Sánchez N, Coura R, Engmann O, Marion-Poll L, Longueville S, Hervé D, Andrés ME, Girault JA (2014) Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32. Neuropharmacology. 79:559-66. [Link]External link
CELLTYPE-SPECIFIC DARPP-32 SIGNALING CASCADE

Radwanska K, Medvedev NI, Pereira GS, Engmann O, Thiede N, Moraes MF, Villers A, Irvine EE, Maunganidze NS, Pyza EM, Ris L, Szymańska M, Lipiński M, Kaczmarek L, Stewart MG, Giese KP (2011) Mechanism for long-term memory formation when synaptic strengthening is impaired. Proc Natl Acad Sci U S A. 108:18471-5. [Link]External link
DESCRIPTION OF SPECIFIC DENDRITIC SPINE TYPE RELEVANT TO MEMORY

Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein HG, Kreutz MR, Mill J, Nikolic M, Giese KP (2011) Schizophrenia is associated with dysregulation of a CDK5 activator that regulates synaptic protein expression and cognition. Brain. 134:2408-21. [Link]External link 
NEW PATHWAY RELEVANT TO SCHIZOPHRENIA VIA P35-CDK5 AND HDAC1

Engmann O, Hortobágyi T, Thompson AJ, Guadagno J, Troakes C, Soriano S, Al-Sarraj S, Kim Y, Giese KP (2011) Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol Psychiatry. 70:159-68. [Link]External link
P25-CDK5 PROMOTES COGNITION AND IS REDUCED IN ALZHEIMER’S DISEASE

Michels B, Chen YC, Saumweber T, Mishra D, Tanimoto H, Schmid B, Engmann O, Gerber B (2011) Cellular site and molecular mode of synapsin action in associative learning. Learn Mem. 18:332-44. [Link]External link
SYNAPTIC SIGNALING IN DROSOPHILA LEARNING

Engmann O, Campbell J, Ward M, Giese KP, Thompson AJ (2010) Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags. J Proteome Res. 9:2725-33. [Link]External link
DEVELOPMENT OF PROTEOMICS PIPELINE FOR QUANTITATIVE MASSPEC ON SYNAPTOSOMES

Engmann O, Giese KP (2009) Crosstalk between CDK5 and GSK3beta: Implications for Alzheimer's Disease. Front Mol Neurosci. 2:2. [Link]External link
REVIEW ON CONTROVERSIAL TAU KINASES

Sung JY, Engmann O, Teylan MA, Nairn AC, Greengard P, Kim Y (2008) WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A. 105:3112-6. [Link]External link
PATHWAY OF SPINE REGULATION VIA MITOCHONDRIAL DYNAMICS

Book chapters

Engmann O. (2021) How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another.
Adv Exp Med Biol. (Springer) 1344: 129-152. [Link]External link

Engmann O, Mansuy, I.M (2020) Stress and its effects across generations. In: Chen, Alon. Stress Resilience, Molecular and Behavioral Aspects. London: Elsevier, 269-290. [Link]External link

Books

Engmann O, Brancaccio M. (2021) The circadian clock in brain health and disease. Springer [Link]External link