MBC.A18

Epigenetic Mechanisms of Gene Regulation

Module description

Module coordinator

Prof. Dr. Thorsten Heinzel

Requirements for module admission

Enrolment in one basic module

Module is required for

Specialization module

Type of module

Required elective module, advanced module

Frequency of offer (module cycle)

Yearly

Duration of module

2 Semesters

Composition of module / types of components (lecture, exercise, seminar, practical training, excursion)

Practical training: 5 hours per week per semester

Seminar: 1 hour per week per semester

Credit points (ECTS credits)

10 cp

Work load in hours:

  • In-class studying
  • Self-study (incl. exam preparation)

105 h

195 h

Contents

This module focuses on epigenetic gene regulation in eukaryotic development and pathogenesis. The goal is to provide an advanced insight into the role of epigenetic modifications and associated modifiers in transcriptional activation and repression. In this context, we will also discuss the functionality of posttranslational modifications of transcription factors. In addition, we will deepen the understanding of the epigenome’s dynamics and resulting consequences for health and therapy, with special regard to epigenome-manipulating drugs (e.g. inhibitors of epigenetic modifiers). Moreover, we will discuss the interpretation of posttranslational modifications of histones (The Histone Code) as well as consequences for transcriptional regulation. We will cover recent high impact publications and reviews. Furthermore, there will be a lab internship in one of the participating research groups.

Learning and qualification objectives

In-depth studies of transcriptional regulation in eukaryotes to improve the basic knowledge. Seminar presentation based on independent study and analysis of recent publications. Hands-on training of state-of the art techniques in the field of epigenetic gene regulation.

To achieve the goals of this module seminars and internships have to be attended on a regular basis.

Requirements for admission to module exam

None

Requirements for the award of credit points; exams (weighting of grades in %)

Oral exam (70%)

Seminar presentation (30%)

Proof of participation in practical training